Protoapigenone

Cat. No.: HY-134008 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively.

For research use only. We do not sell to patients.

Protoapigenone Chemical Structure

CAS No. : 862884-32-0

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 850	Get quote	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	13.85 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
HEK293	IC₅₀	6.79 μM Compound: 1	Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
Hep 3B2	IC₅₀	2.27 μM Compound: 1	Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
HepG2	IC₅₀	7.77 μM Compound: 1	Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
HepG2	IC₅₀	8.11 μM Compound: 1	Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
MCF7	IC₅₀	3.74 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
MCF7	IC₅₀	5.5 μM Compound: 1	Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
MDA-MB-231	IC₅₀	1.43 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method	[PMID: 17622129]
MDA-MB-231	IC₅₀	1.7 μM Compound: 1	Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
PANC-1	IC₅₀	22.09 μM Compound: 1	Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
PBMC	IC₅₀	8.11 μM Compound: 1	Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
PC-3	IC₅₀	6.13 μM Compound: 1	Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
RPMI-8226	IC₅₀	3.93 μM Compound: 1	Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
SK-OV-3	IC₅₀	0.71 μM Compound: 1	Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]
U-266	IC₅₀	7.66 μM Compound: 1	Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay	[PMID: 21515048]

Molecular Weight

286.24

Formula

C₁₅H₁₀O₆

CAS No.

862884-32-0

Appearance

Solid

Color

White to light yellow

SMILES

OC1=C2C(OC(C3(O)C=CC(C=C3)=O)=CC2=O)=CC(O)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (249 KB) HNMR (143 KB) CNMR (177 KB) RP-HPLC (243 KB) MS (135 KB)

Handling Instructions (2659 KB)

References

[1]. Lin A S, et al. New cytotoxic flavonoids from Thelypteris torresiana[J]. Planta medica, 2005, 71(09): 867-870.

Protoapigenone Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protoapigenone862884-32-0Othersantineoplastic agentInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Protoapigenone

Customer Review

Protoapigenone Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Protoapigenone Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report