2. Anti-infection
  3. Antibiotic Reverse Transcriptase
  4. Protorubradirin

Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin.

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Protorubradirin Chemical Structure

Protorubradirin Chemical Structure

CAS No. : 122525-61-5

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Protorubradirin Related Antibodies

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Description

Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin[1].

IC50 & Target

HIV Reverse Transcriptase[1]
Molecular Weight

982.89

Formula

C48H46N4O19
CAS No.
SMILES

O=C(C(O1)=C2NCC1(C(C3O)=O)C)C(C(C2=O)=C4)=C(C(/C(C)=C/C(C3OC(C(N=C5C(NC(C(OC6=C7)=O)=C(C6=CC=C7OC)O)=O)=C(C(OC(OC8C)CC(C)(C8OC)N=O)=C5)O)=O)C)=O)C(O)=C4C
Structure Classification
Initial Source

Streptomyces achromogenes var.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Protorubradirin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protorubradirin122525-61-5AntibioticReverse TranscriptaseInhibitorinhibitorinhibit

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