Protorubradirin

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Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin.

For research use only. We do not sell to patients.

Protorubradirin Chemical Structure

CAS No. : 122525-61-5

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Description	Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin^[1].
IC₅₀ & Target	HIV Reverse Transcriptase^[1]
Molecular Weight	982.89
Formula	C₄₈H₄₆N₄O₁₉
CAS No.	122525-61-5
SMILES	O=C(C(O1)=C2NCC1(C(C3O)=O)C)C(C(C2=O)=C4)=C(C(/C(C)=C/C(C3OC(C(N=C5C(NC(C(OC6=C7)=O)=C(C6=CC=C7OC)O)=O)=C(C(OC(OC8C)CC(C)(C8OC)N=O)=C5)O)=O)C)=O)C(O)=C4C
Structure Classification	Antibiotics Other Antibiotics
Initial Source	Microorganisms Streptomyces achromogenes var.
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. PROTORUBRADIRIN, AN ANTIBIOTIC CONTAINING A C-NITROSO-SUGAR FRAGMENT, IS THE TRUE SECONDARY METABOLITE PRODUCED BY