2. GPCR/G Protein Apoptosis
  3. P2Y Receptor Apoptosis
  4. PSB 0474

PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis.

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PSB 0474 Chemical Structure

PSB 0474 Chemical Structure

CAS No. : 917567-60-3

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PSB 0474 Related Antibodies

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Description

PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].

IC50 & Target

IC50: 70 nM (P2Y6)[1]
Molecular Weight

522.29

Formula

C17H20N2O13P2
CAS No.
SMILES

O[C@H]([C@@H]1O)[C@@](N(C=CC2=O)C(N2CC(C3=CC=CC=C3)=O)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PSB 0474 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB 0474917567-60-3PSB0474PSB-0474P2Y ReceptorApoptosismicrogliaastrocyteNO releaseInhibitorinhibitorinhibit

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HY-108654
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