Pseudorabies virus-IN-1 

Pseudorabies virus-IN-1 is a potent pseudorabies virus (PRV) inhibitor (EC₅₀: 0.29 nM). Pseudorabies virus-IN-1 inhibits PRV replication by targeting PRV deoxyribonucleic acid polymerase (DNA pol). Pseudorabies virus-IN-1 can effectively inhibit PRV replication at low concentrations (MIC₈₀: 1.6-8 nM). Pseudorabies virus-IN-1 can be used to study PRV infection^[1].

Pseudorabies virus-IN-1 (Compound C2) (0.1-1000 nM, 48 h) can inhibit 50% of PRV replication in PK15 cells infected with PRV (MOI=1) at very low concentrations (EC₅₀: 0.29 nM), shows significant activity^[1].
Pseudorabies virus-IN-1 (0.05-100 nM, 72 h) has relatively low cytotoxicity in PK15 cells (CC₅₀: 28 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pseudorabies virus-IN-1 (Compound C2) (30 mg/kg, i.p. three times daily for 7 consecutive days) reduces viral load in mouse brain tissue by > 99% compared with the control group (treatment group: 2.8×10³-2.3×10⁵ copies/g; control group: 9.5×10⁵-1.6×10¹⁰ copies/g)^[1].
Pseudorabies virus-IN-1 (30 mg/kg, i.p. three times daily for 7 consecutive days) makes all mice in the treatment group survive, while the mortality rate of the control group reached 80%, and the number of viral copies in the treatment group was significantly lower than that in the control group (about 3 times less).^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

508.95

C₂₇H₂₃ClF₂N₄O₂

O=C1C(C(NCC2=CC(Cl)=CC=C2F)=O)=CN(C3=CC=CC=C3)C4=C1C=C(F)C(N5CCNCC5)=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wei L, et al. Rapid discovery of pseudorabies virus inhibitors repurposed from the antimicrobial agent ciprofloxacin. Eur J Med Chem. 2025 May 5;289:117490.  [Content Brief]