2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Bacterial Antibiotic
  4. Pseudouridimycin

Pseudouridimycin  (Synonyms: PUM)

Cat. No.: HY-125650 Purity: ≥96.0%
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Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and a minimum inhibitory concentration (MIC) of 4 - 6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.

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Pseudouridimycin Chemical Structure

Pseudouridimycin Chemical Structure

CAS No. : 1566586-52-4

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Based on 1 publication(s) in Google Scholar

Pseudouridimycin Related Antibodies

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1 Publications Citing Use of MCE Pseudouridimycin

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Description

Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and a minimum inhibitory concentration (MIC) of 4 - 6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2].

Molecular Weight

486.44

Formula

C17H26N8O9
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC(C([C@H]2[C@@H]([C@@H]([C@@H](CNC([C@H](CCC(N)=O)N(C(CNC(N)=N)=O)O)=O)O2)O)O)=CN1)=O
Structure Classification
Initial Source

treptomyces sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥96.0%

SDS (251 KB)

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Handling Instructions (2659 KB)
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Pseudouridimycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pseudouridimycin1566586-52-4PUMDNA/RNA SynthesisBacterialAntibioticInhibitorinhibitorinhibit

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