2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. PTDA-PEG4-azide

PTDA-PEG4-azide  (Synonyms: PTAD-PEG4-N3)

Cat. No.: HY-130940 Purity: 99.34%
SDS COA Handling Instructions Technical Support

PTAD-PEG4-N3 is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PTAD-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

PTDA-PEG4-azide Chemical Structure

PTDA-PEG4-azide Chemical Structure

CAS No. : 2639395-40-5

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Based on 1 publication(s) in Google Scholar

PTDA-PEG4-azide Related Antibodies

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Description

PTAD-PEG4-N3 is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PTAD-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTDA-PEG4-azide Related Antibodies
Molecular Weight

539.54

Formula

C22H33N7O9
CAS No.
Appearance

Oil

Color

White to off-white

SMILES

O=C(NNC1=O)N1C2=CC=C(OCCNC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)C(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (231.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8534 mL 9.2672 mL 18.5343 mL
5 mM 0.3707 mL 1.8534 mL 3.7069 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8534 mL 9.2672 mL 18.5343 mL 46.3358 mL
5 mM 0.3707 mL 1.8534 mL 3.7069 mL 9.2672 mL
10 mM 0.1853 mL 0.9267 mL 1.8534 mL 4.6336 mL
15 mM 0.1236 mL 0.6178 mL 1.2356 mL 3.0891 mL
20 mM 0.0927 mL 0.4634 mL 0.9267 mL 2.3168 mL
25 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8534 mL
30 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5445 mL
40 mM 0.0463 mL 0.2317 mL 0.4634 mL 1.1584 mL
50 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
60 mM 0.0309 mL 0.1545 mL 0.3089 mL 0.7723 mL
80 mM 0.0232 mL 0.1158 mL 0.2317 mL 0.5792 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.4634 mL
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PTDA-PEG4-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTDA-PEG4-azide2639395-40-5PTAD-PEG4-N3ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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