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PTIO is a specific scavenger of NO. PTIO reacts with •NO to form the corresponding imino nitroxides and •NO2.

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PTIO Chemical Structure

PTIO Chemical Structure

CAS No. : 18390-00-6

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50 mg USD 80 In-stock
100 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

PTIO Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

PTIO is a specific scavenger of NO. PTIO reacts with •NO to form the corresponding imino nitroxides and •NO2[1].

Cellular Effect
Cell Line Type Value Description References
PC-12 EC50
51.63 μM
Compound: 1
Hydrogen peroxide radical scavenging activity in PC12 cell by survival assay
Hydrogen peroxide radical scavenging activity in PC12 cell by survival assay
[PMID: 17306423]
PC-12 EC50
66.51 μM
Compound: 1
Hydroxyl radical scavenging activity in PC12 cell by survival assay
Hydroxyl radical scavenging activity in PC12 cell by survival assay
[PMID: 17306423]
PC-12 EC50
67.61 μM
Compound: 1
Nitric oxide radical scavenging activity in PC12 cells by survival assay
Nitric oxide radical scavenging activity in PC12 cells by survival assay
[PMID: 17306423]
Molecular Weight

233.29

Formula

C13H17N2O2
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

[O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (428.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 12.5 mg/mL (53.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2865 mL 21.4326 mL 42.8651 mL
5 mM 0.8573 mL 4.2865 mL 8.5730 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.09%

SDS (393 KB)

COA (256 KB) RP-HPLC (249 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.2865 mL 21.4326 mL 42.8651 mL 107.1628 mL
5 mM 0.8573 mL 4.2865 mL 8.5730 mL 21.4326 mL
10 mM 0.4287 mL 2.1433 mL 4.2865 mL 10.7163 mL
15 mM 0.2858 mL 1.4288 mL 2.8577 mL 7.1442 mL
20 mM 0.2143 mL 1.0716 mL 2.1433 mL 5.3581 mL
25 mM 0.1715 mL 0.8573 mL 1.7146 mL 4.2865 mL
30 mM 0.1429 mL 0.7144 mL 1.4288 mL 3.5721 mL
40 mM 0.1072 mL 0.5358 mL 1.0716 mL 2.6791 mL
50 mM 0.0857 mL 0.4287 mL 0.8573 mL 2.1433 mL
DMSO 60 mM 0.0714 mL 0.3572 mL 0.7144 mL 1.7860 mL
80 mM 0.0536 mL 0.2679 mL 0.5358 mL 1.3395 mL
100 mM 0.0429 mL 0.2143 mL 0.4287 mL 1.0716 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PTIO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTIO18390-00-6OthersantioxidantscavengerNOiminonitroxidesInhibitorinhibitorinhibit

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