2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. PTPN2/1-IN-3

PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice.

For research use only. We do not sell to patients.

PTPN2/1-IN-3 Chemical Structure

PTPN2/1-IN-3 Chemical Structure

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PTPN2/1-IN-3 Related Antibodies

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Description

PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice[1].

IC50 & Target

IC50: 9.3 nM (PTPN2)[1]
Molecular Weight

343.37

Formula

C14H18FN3O4S
SMILES

FC1=C(N2CC(NS2(=O)=O)=O)C(O)=CC3=C1CCN(CC)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PTPN2/1-IN-3 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTPN2/1-IN-3PhosphataseInhibitorinhibitorinhibit

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