2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. PU24FCl

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue.

For research use only. We do not sell to patients.

PU24FCl Chemical Structure

PU24FCl Chemical Structure

CAS No. : 422508-46-1

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PU24FCl Related Antibodies

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Description

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue[1].

IC50 & Target[1]

HSP90

 

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
1.2 μM
Compound: PUC24FCI
Antiproliferative activity against human MCF7 cells by MTS assay
Antiproliferative activity against human MCF7 cells by MTS assay
[PMID: 17488003]
SK-BR-3 IC50
0.66 μM
Compound: PU24FCl
Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay
Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay
[PMID: 24548207]
SK-BR-3 IC50
2 μM
Compound: PU24FCl
Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
[PMID: 24548207]
SK-BR-3 IC50
2.5 μM
Compound: PU24FCl
Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis
Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis
[PMID: 24548207]
SK-BR-3 IC50
2.9 μM
Compound: PU24FCl
Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay
Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay
[PMID: 24548207]
Molecular Weight

433.86

Formula

C20H21ClFN5O3
CAS No.
SMILES

FC1=NC2=C(N=C(CC3=CC(OC)=C(C(OC)=C3Cl)OC)N2CCCC#C)C(N)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PU24FCl Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PU24FCl422508-46-1HSPHeat shock proteinsanticancerInhibitorinhibitorinhibit

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