PU24FCl

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PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue.

For research use only. We do not sell to patients.

PU24FCl Chemical Structure

CAS No. : 422508-46-1

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Biological Activity
Purity & Documentation
References
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Description

PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue^[1].

IC₅₀ & Target^[1]

HSP90

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	1.2 μM Compound: PUC24FCI	Antiproliferative activity against human MCF7 cells by MTS assay Antiproliferative activity against human MCF7 cells by MTS assay	[PMID: 17488003]
SK-BR-3	IC₅₀	0.66 μM Compound: PU24FCl	Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay	[PMID: 24548207]
SK-BR-3	IC₅₀	2 μM Compound: PU24FCl	Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis	[PMID: 24548207]
SK-BR-3	IC₅₀	2.5 μM Compound: PU24FCl	Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis	[PMID: 24548207]
SK-BR-3	IC₅₀	2.9 μM Compound: PU24FCl	Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay	[PMID: 24548207]

Molecular Weight

433.86

Formula

C₂₀H₂₁ClFN₅O₃

CAS No.

422508-46-1

SMILES

FC1=NC2=C(N=C(CC3=CC(OC)=C(C(OC)=C3Cl)OC)N2CCCC#C)C(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vilenchik M, et, al. Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chem Biol. 2004 Jun;11(6):787-97. [Content Brief]

PU24FCl Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PU24FCl422508-46-1HSPHeat shock proteinsanticancerInhibitorinhibitorinhibit

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