2. GPCR/G Protein Neuronal Signaling PI3K/Akt/mTOR Autophagy
  3. 5-HT Receptor mTOR Autophagy
  4. PUC-10

PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. In silico predictions suggest that PUC-10 is orally active and can cross the blood-brain barrier. PUC-10 can induce autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 can be used in the research of neurological disorders.

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PUC-10 Chemical Structure

PUC-10 Chemical Structure

CAS No. : 2095549-31-6

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PUC-10 Related Antibodies

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Description

PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. In silico predictions suggest that PUC-10 is orally active and can cross the blood-brain barrier. PUC-10 can induce autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 can be used in the research of neurological disorders[1].

Molecular Weight

541.66

Formula

C31H31N3O4S
CAS No.
SMILES

COC1=C(C=CC=C1)N2CCN(CC2)C[C@H](C3=CN(C4=CC=CC=C34)S(=O)(C5=CC=CC6=C5C=CC=C6)=O)O
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Room temperature in continental US; may vary elsewhere.
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PUC-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PUC-102095549-31-6PUC10PUC 105-HT ReceptormTORAutophagySerotonin Receptor5-hydroxytryptamine ReceptorMammalian target of RapamycinSH-SY5YInhibitorinhibitorinhibit

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