2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. PYD-106

PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors.

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PYD-106 Chemical Structure

PYD-106 Chemical Structure

CAS No. : 1560894-05-4

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Based on 1 publication(s) in Google Scholar

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Description

PYD-106 is a stereoselective pyrrolidinone (PYD) positive allosteric modulator for GluN2C-containing NMDA receptors. PYD-106 increases opening frequency and open time of single channel currents activated by maximally effective concentrations of agonist but only has modest effects on glutamate and glycine EC50. PYD-106 selectively enhances the responses of diheteromeric GluN1/GluN2C receptors but not triheteromeric GluN1/GluN2A/GluN2C receptors[1].

Molecular Weight

432.47

Formula

C25H24N2O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC)C1=CC=C(C(C(C(C)=O)=C2O)N(CCC3=C(C)NC4=C3C=CC=C4)C2=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (289.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3123 mL 11.5615 mL 23.1230 mL
5 mM 0.4625 mL 2.3123 mL 4.6246 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3123 mL 11.5615 mL 23.1230 mL 57.8075 mL
5 mM 0.4625 mL 2.3123 mL 4.6246 mL 11.5615 mL
10 mM 0.2312 mL 1.1561 mL 2.3123 mL 5.7807 mL
15 mM 0.1542 mL 0.7708 mL 1.5415 mL 3.8538 mL
20 mM 0.1156 mL 0.5781 mL 1.1561 mL 2.8904 mL
25 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3123 mL
30 mM 0.0771 mL 0.3854 mL 0.7708 mL 1.9269 mL
40 mM 0.0578 mL 0.2890 mL 0.5781 mL 1.4452 mL
50 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1561 mL
60 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9635 mL
80 mM 0.0289 mL 0.1445 mL 0.2890 mL 0.7226 mL
100 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5781 mL
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PYD-106 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PYD-1061560894-05-4PYD106PYD 106iGluRIonotropic glutamate receptorsstereoselectiveallosteric modulatorGluN2CNMDAInhibitorinhibitorinhibit

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