2. Cell Cycle/DNA Damage Autophagy
  3. Deubiquitinase Mitophagy
  4. Q14

Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism.

For research use only. We do not sell to patients.

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Q14 Chemical Structure

Q14 Chemical Structure

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Q14 Related Antibodies

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USP1 USP2 USP7 USP8 USP30 UCHL1

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Description

Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism[1].

IC50 & Target[1]

USP30

57.2 nM (IC50)

Molecular Weight

2156.58

Formula

C99H166N32O22
Sequence

Gly-Ile-Tyr-Val-Ile-Trp-Gly-Pro-Ile-Thr-Glu-Arg-Lys-Lys-Arg-Arg-Lys-Gly-NH2
Sequence Shortening

GIYVIWGPITERKKRRKG-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Q14 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Q14Q14 peptideQ 14Q-14DeubiquitinaseMitophagyDUBsMitochondrial AutophagyUSP30peptidedeubiquitinationLC3mitochondrial autophagyneurodegenerative diseasesInhibitorinhibitorinhibit

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