QL-IX-55

Cat. No.: HY-15281: FAQs
Data Sheet Handling Instructions

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QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC₅₀s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.

For research use only. We do not sell to patients.

QL-IX-55 Chemical Structure

CAS No. : 1223002-54-7

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mTOR mTORC1 mTORC2

Biological Activity
Purity & Documentation
References
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Description

QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC₅₀s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively.

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	EC₅₀	250 nM Compound: 11	Inhibition of PI3Kalpha in human PC3 cells expressing Akt1 S473D mutant assessed as phosphorylation of Akt Thr308 by immunoblotting Inhibition of PI3Kalpha in human PC3 cells expressing Akt1 S473D mutant assessed as phosphorylation of Akt Thr308 by immunoblotting	[PMID: 21322566]

Molecular Weight

450.39

Formula

C₂₄H₁₄F₄N₄O

CAS No.

1223002-54-7

SMILES

NC1=NC=C(C2=CC=C(N=CC(C=C3)=C4N(C5=CC(C(F)(F)F)=C(F)C=C5)C3=O)C4=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Akiyoshi-Shibata M, et al. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli. Eur J Biochem. 1994 Sep 1;224(2):335-43. [Content Brief]

QL-IX-55 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QL-IX-551223002-54-7mTORMammalian target of RapamycinInhibitorinhibitorinhibit

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