Quinocarcin  (Synonyms: Quinocarmycin; DC-52; KW2152 free base)

Quinocarcin (DC-52) is a potent antitumor antibiotic. Quinocarcin inhibits Bacillus subtilis DNA, RNA and protein syntheses^[1][2].

Quinocarcin (100 µg/mM; 0-20 min) inhibits ^{Bacillus subtilis} DNA, RNA and protein syntheses^[1].
Quinocarcin (0.1, 1, 10 mM) interactes with PM2 DNA in a dose-dependent manner^[1].
Quinocarcin (0-100 µM) shows cell cytotoxicity with LC₅₀ values of >100, 3.18, 3.83, 0.49, 84.85, 43.27 µM for LOX-IMVI; SK-MEL-5, UACC-62, UACC-257, MALME-3M cells, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinocarcin (40 mg/kg, i.p.) shows antitumor activity in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

330.38

C₁₈H₂₂N₂O₄

84573-33-1

O=C(O)[C@@H]1[C@]2([C@]([H])(N3[C@@]4(CO[C@]3([C@@]([H])(C1)N2C)[H])[H])CC5=C4C(OC)=CC=C5)[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tomita F, et al. Quinocarcin, a novel antitumor antibiotic. 3. Mode of action. J Antibiot (Tokyo). 1984 Oct;37(10):1268-72.  [Content Brief]

  [2]. Kahsai AW, et al. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chem Biol. 2006 Sep;13(9):973-83.  [Content Brief]

  [3]. Plowman J, et al. Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture kand in mice. Cancer Res. 1995 Feb 15;55(4):862-7.  [Content Brief]