(R)-Efavirenz (Synonyms: (R)-DMP 266; (R)-EFV; (R)-L-743726)

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(R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms.

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(R)-Efavirenz Chemical Structure

CAS No. : 154801-74-8

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Description	(R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms^[1]^[2].
Molecular Weight	315.67
Formula	C₁₄H₉ClF₃NO₂
CAS No.	154801-74-8
SMILES	FC(F)(F)[C@]1(C2=CC(Cl)=CC=C2NC(O1)=O)C#CC3CC3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Maggiolo F. Efavirenz. Expert Opin Pharmacother. 2007 Jun;8(8):1137-45. [Content Brief] [2]. Wang PF, et al. Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry. Drug Metab Dispos. 2019 Oct;47(10):1195-1205. doi: 10.1124/dmd.119.086348. Epub 2019 Jul 19. Erratum in: Drug Metab Dispos. 2019 Oct;47(10):1231. [Content Brief]

(R)-Efavirenz Related Classifications

Infection

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Efavirenz154801-74-8(R)-DMP 266 (R)-EFV (R)-L-743726Reverse Transcriptasenon-nucleoside reverse transcriptaseviral enzymeCYP2B68-hydroxyefavirenzstereoselectiveInhibitorinhibitorinhibit

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(R)-Efavirenz (Synonyms: (R)-DMP 266; (R)-EFV; (R)-L-743726)

Other Forms of (R)-Efavirenz:

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