2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. (R)-Fasiglifam

(R)-Fasiglifam  (Synonyms: (R)-TAK-875)

Cat. No.: HY-10480A Purity: 98.95%
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(R)-Fasiglifam is the isomer of Fasiglifam (HY-10480), and can be used as an experimental control. Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.

For research use only. We do not sell to patients.

(R)-Fasiglifam Chemical Structure

(R)-Fasiglifam Chemical Structure

CAS No. : 1234474-57-7

Size Price Stock Quantity
1 mg USD 260 In-stock
5 mg USD 520 In-stock
10 mg USD 780 In-stock
25 mg USD 1500 In-stock
50 mg USD 2250 In-stock
100 mg USD 3150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-Fasiglifam:

(R)-Fasiglifam Related Antibodies

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Description

(R)-Fasiglifam is the isomer of Fasiglifam (HY-10480), and can be used as an experimental control. Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.

Molecular Weight

524.63

Formula

C29H32O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C(C)=CC(OCCCS(C)(=O)=O)=C1)C2=CC(COC3=CC=C([C@H](CO4)CC(O)=O)C4=C3)=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (190.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9061 mL 9.5305 mL 19.0611 mL
5 mM 0.3812 mL 1.9061 mL 3.8122 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9061 mL 9.5305 mL 19.0611 mL 47.6526 mL
5 mM 0.3812 mL 1.9061 mL 3.8122 mL 9.5305 mL
10 mM 0.1906 mL 0.9531 mL 1.9061 mL 4.7653 mL
15 mM 0.1271 mL 0.6354 mL 1.2707 mL 3.1768 mL
20 mM 0.0953 mL 0.4765 mL 0.9531 mL 2.3826 mL
25 mM 0.0762 mL 0.3812 mL 0.7624 mL 1.9061 mL
30 mM 0.0635 mL 0.3177 mL 0.6354 mL 1.5884 mL
40 mM 0.0477 mL 0.2383 mL 0.4765 mL 1.1913 mL
50 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.9531 mL
60 mM 0.0318 mL 0.1588 mL 0.3177 mL 0.7942 mL
80 mM 0.0238 mL 0.1191 mL 0.2383 mL 0.5957 mL
100 mM 0.0191 mL 0.0953 mL 0.1906 mL 0.4765 mL
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(R)-Fasiglifam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Fasiglifam1234474-57-7(R)-TAK-875Free Fatty Acid ReceptorFFARInhibitorinhibitorinhibit

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