R-(–)-Flecainide

Cat. No.: HY-124883 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity.

For research use only. We do not sell to patients.

R-(–)-Flecainide Chemical Structure

CAS No. : 99495-90-6

Size	Price	Stock	Quantity
1 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 470	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Purity & Documentation
References
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Description

R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity^[1].

In Vivo

R-(–)-Flecainide inhibits chloroform-induced fibrillation (9-20 mg/kg, po, single dose) in mice model with an ED₅₀ of 14.5 mg/kg, and inhibits ouabain induced arrhythmias (1-3 mg/kg, ) in mongrel dog model, without toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Chloroform-induced ventricular fibrillation in mice^[1]
Dosage:	9-20 mg/kg
Administration:	po, single dose
Result:	Prevented fibrillation.

Animal Model:	Ouabain induced ventricular tachycardia in mongrel dog^[1]
Dosage:	1-3 mg/kg
Administration:	iv, single dose
Result:	Inhibited arrhythmias.

Molecular Weight

414.34

Formula

C₁₇H₂₀F₆N₂O₃

CAS No.

99495-90-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C=CC(OCC(F)(F)F)=C1)OCC(F)(F)F)NC[C@H]2CCCCN2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (241.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4135 mL	12.0674 mL	24.1348 mL
5 mM	0.4827 mL	2.4135 mL	4.8270 mL
10 mM	0.2413 mL	1.2067 mL	2.4135 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB) HNMR (261 KB) RP-HPLC (268 KB) LCMS (139 KB)

Handling Instructions (2659 KB)

References

[1]. Banitt EH, et al., Resolution of flecainide acetate, N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzam ide acetate, and antiarrhythmic properties of the enantiomers. J Med Chem. 1986 Feb;29(2):299-302. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4135 mL	12.0674 mL	24.1348 mL	60.3369 mL
	5 mM	0.4827 mL	2.4135 mL	4.8270 mL	12.0674 mL
	10 mM	0.2413 mL	1.2067 mL	2.4135 mL	6.0337 mL
	15 mM	0.1609 mL	0.8045 mL	1.6090 mL	4.0225 mL
	20 mM	0.1207 mL	0.6034 mL	1.2067 mL	3.0168 mL
	25 mM	0.0965 mL	0.4827 mL	0.9654 mL	2.4135 mL
	30 mM	0.0804 mL	0.4022 mL	0.8045 mL	2.0112 mL
	40 mM	0.0603 mL	0.3017 mL	0.6034 mL	1.5084 mL
	50 mM	0.0483 mL	0.2413 mL	0.4827 mL	1.2067 mL
	60 mM	0.0402 mL	0.2011 mL	0.4022 mL	1.0056 mL
	80 mM	0.0302 mL	0.1508 mL	0.3017 mL	0.7542 mL
	100 mM	0.0241 mL	0.1207 mL	0.2413 mL	0.6034 mL

R-(–)-Flecainide Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-(–)-Flecainide99495-90-6Othersmongrel dogarrhythmias tachycardiaInhibitorinhibitorinhibit

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