2. Others
  3. Drug Isomer
  4. R-(–)-Flecainide

R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity.

For research use only. We do not sell to patients.

R-(–)-Flecainide Chemical Structure

R-(–)-Flecainide Chemical Structure

CAS No. : 99495-90-6

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Based on 1 publication(s) in Google Scholar

R-(–)-Flecainide Related Antibodies

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Description

R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity[1].

In Vivo

R-(–)-Flecainide inhibits chloroform-induced fibrillation (9-20 mg/kg, po, single dose) in mice model with an ED50 of 14.5 mg/kg, and inhibits ouabain induced arrhythmias (1-3 mg/kg, ) in mongrel dog model, without toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chloroform-induced ventricular fibrillation in mice[1]
Dosage: 9-20 mg/kg
Administration: po, single dose
Result: Prevented fibrillation.
Animal Model: Ouabain induced ventricular tachycardia in mongrel dog[1]
Dosage: 1-3 mg/kg
Administration: iv, single dose
Result: Inhibited arrhythmias.
Molecular Weight

414.34

Formula

C17H20F6N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C=CC(OCC(F)(F)F)=C1)OCC(F)(F)F)NC[C@H]2CCCCN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (241.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4135 mL 12.0674 mL 24.1348 mL
5 mM 0.4827 mL 2.4135 mL 4.8270 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4135 mL 12.0674 mL 24.1348 mL 60.3369 mL
5 mM 0.4827 mL 2.4135 mL 4.8270 mL 12.0674 mL
10 mM 0.2413 mL 1.2067 mL 2.4135 mL 6.0337 mL
15 mM 0.1609 mL 0.8045 mL 1.6090 mL 4.0225 mL
20 mM 0.1207 mL 0.6034 mL 1.2067 mL 3.0168 mL
25 mM 0.0965 mL 0.4827 mL 0.9654 mL 2.4135 mL
30 mM 0.0804 mL 0.4022 mL 0.8045 mL 2.0112 mL
40 mM 0.0603 mL 0.3017 mL 0.6034 mL 1.5084 mL
50 mM 0.0483 mL 0.2413 mL 0.4827 mL 1.2067 mL
60 mM 0.0402 mL 0.2011 mL 0.4022 mL 1.0056 mL
80 mM 0.0302 mL 0.1508 mL 0.3017 mL 0.7542 mL
100 mM 0.0241 mL 0.1207 mL 0.2413 mL 0.6034 mL
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R-(–)-Flecainide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R-(–)-Flecainide99495-90-6Drug Isomermongrel dogarrhythmias tachycardiaInhibitorinhibitorinhibit

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