2. Others
  3. Others
  4. (R)-GDC-0927

(R)-GDC-0927  (Synonyms: (R)-SRN-927)

Cat. No.: HY-120207 Purity: 98.78%
SDS COA Handling Instructions

Molarity Calculator

(R)-GDC-0927 ((R)-SRN-927) is a (R)-enantiomer of GDC-0927 (HY-111484).

For research use only. We do not sell to patients.

(R)-GDC-0927 Chemical Structure

(R)-GDC-0927 Chemical Structure

CAS No. : 1642297-53-7

Size Price Stock Quantity
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-GDC-0927:

(R)-GDC-0927 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R)-GDC-0927 ((R)-SRN-927) is a (R)-enantiomer of GDC-0927 (HY-111484)[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
13 nM
Compound: 17hb
Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assay
Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha protein level after 4 hrs by InCell Western assay
[PMID: 30655946]
Molecular Weight

461.52

Formula

C28H28FNO4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)[C@@H](C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1668 mL 10.8338 mL 21.6675 mL
5 mM 0.4334 mL 2.1668 mL 4.3335 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.78%

SDS (393 KB)

COA (247 KB) HNMR (145 KB) LCMS (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1668 mL 10.8338 mL 21.6675 mL 54.1688 mL
5 mM 0.4334 mL 2.1668 mL 4.3335 mL 10.8338 mL
10 mM 0.2167 mL 1.0834 mL 2.1668 mL 5.4169 mL
15 mM 0.1445 mL 0.7223 mL 1.4445 mL 3.6113 mL
20 mM 0.1083 mL 0.5417 mL 1.0834 mL 2.7084 mL
25 mM 0.0867 mL 0.4334 mL 0.8667 mL 2.1668 mL
30 mM 0.0722 mL 0.3611 mL 0.7223 mL 1.8056 mL
40 mM 0.0542 mL 0.2708 mL 0.5417 mL 1.3542 mL
50 mM 0.0433 mL 0.2167 mL 0.4334 mL 1.0834 mL
60 mM 0.0361 mL 0.1806 mL 0.3611 mL 0.9028 mL
80 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6771 mL
100 mM 0.0217 mL 0.1083 mL 0.2167 mL 0.5417 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(R)-GDC-0927 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-GDC-09271642297-53-7(R)-SRN-927OthersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(R)-GDC-0927
Cat. No.:
HY-120207
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.