(R)-Hydroxychloroquine (Synonyms: (R)-HCQ)

Cat. No.: HY-B1370B: FAQs
Data Sheet Handling Instructions

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(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

For research use only. We do not sell to patients.

(R)-Hydroxychloroquine Chemical Structure

CAS No. : 137433-23-9

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Other Forms of (R)-Hydroxychloroquine:

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Biological Activity
Purity & Documentation
References
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Description

(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine^[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro^[2]^[3]^[4].

IC₅₀ & Target

Plasmodium

TLR7

TLR9

Molecular Weight

335.87

Formula

C₁₈H₂₆ClN₃O

CAS No.

137433-23-9

SMILES

CCN(CCO)CCC[C@H](NC1=CC=NC2=CC(Cl)=CC=C12)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37(4):703-8. [Content Brief]

[2]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6. [Content Brief]

[3]. . Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. [Content Brief]

(R)-Hydroxychloroquine Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Hydroxychloroquine137433-23-9(R)-HCQParasiteToll-like Receptor (TLR)SARS-CoVAutophagySARS coronavirusenantioselectiveSARS-CoV-2malarialenantiomerInhibitorinhibitorinhibit

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