(R)-OY-101

Cat. No.: HY-149053B: FAQs
Data Sheet Handling Instructions

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(R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research.

For research use only. We do not sell to patients.

(R)-OY-101 Chemical Structure

CAS No. : 23495-82-1

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Other Forms of (R)-OY-101:

OY-101 Get quote
(S)-OY-101 Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

(R)-OY-101 increases the cytotoxicity of Vincristine (HY-N0488A) on Eca109/VCR cells with an IC₅₀ value of 9.9 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic (PK) parameters of OY-101 in SD Rats^[1]
Notes: (R)-OY-101 is a stereoscopic configuration of OY-101.

Administration manner	T_max (h)	C_max (ng/mL)	λ_z (1/h)	T_1/2 (h)	MRT_0-inf (h)	AUC_0-t (ng /mL•h)	AUC_0-inf (ng /mL•h)	AUMC_0-inf (ng /mL•h²)	V_z/F (L/kg)	Cl/F (L/kg/h)	F (%)
Intravenous injection	0.17±0.12	1573.20±143.97	0.15±0.13	8.43±7.83	2.68±0.47	2688.45±180.10	2742.45±218.99	7391.35±1874.05	12.84±11.33	1.10±0.08
Oral gavage	0.38±0.18	636.55±355.60	0.12±0.08	7.37±4.92	4.89±1.01	2665.45±450.92	2737.40±515.20	131110.55±237.09	111.27±56.82	11.16±2.10	7.65±2.15

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

433.54

Formula

C₂₇H₃₁NO₄

CAS No.

23495-82-1

SMILES

CN1[C@H](CC2=CC=C(OC)C(OCC3=CC=CC=C3)=C2)C4=C(C=C(OC)C(OC)=C4)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zeng R, et al. Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy. J Med Chem. 2023 Mar 23;66(6):4086-4105. [Content Brief]

(R)-OY-101 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-OY-10123495-82-1P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Eca109/VCRVincristineVCRInhibitorinhibitorinhibit

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