2. Anti-infection Cell Cycle/DNA Damage Cytoskeleton
  3. Antibiotic Microtubule/Tubulin
  4. Vincristine

Vincristine  (Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine)

Cat. No.: HY-N0488A
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Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Vincristine sulfate) that retains the same biological activity.

For research use only. We do not sell to patients.

Vincristine Chemical Structure

Vincristine Chemical Structure

CAS No. : 57-22-7

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Vincristine Related Antibodies

Top Publications Citing Use of Products

53 Publications Citing Use of MCE Vincristine

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    Vincristine purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2019 Jan 30;128:574-582.  [Abstract]

    SGC7901/DDP or SGC7901/VCR cells are transfectedwith si-Con or si-ERK, and transfection efficiency is evaluated by western blot assay at 48 h post transfection.

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    Description

    Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas[1][2].

    Molecular Weight

    824.96

    Formula

    C46H56N4O10
    CAS No.
    SMILES

    CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C4=CC([C@](C5=C6C7=CC=CC=C7N5)(C[C@](C[C@](CC)(O)C8)([H])C[N@@]8CC6)C(OC)=O)=C(OC)C=C4N9C=O)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Vincristine Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vincristine57-22-7Leurocristine NSC-67574 22-OxovincaleukoblastineNSC67574NSC 67574NSC-67574AntibioticMicrotubule/TubulinInhibitorinhibitorinhibit

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