(R)-Phenylpiracetam  (Synonyms: MRZ 9547)

(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (K_i: 14.8 μM; IC₅₀: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders^[1][2].

Ki: 14.8 μM (DAT); IC50: 65.5 μM (DAT)^[2]

(R)-Phenylpiracetam displaces the binding of [¹²⁵I] RTI-55 (IC₅₀ = 4.82 μM) to human recombinant DAT expressed in CHO-K1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Phenylpiracetam (50 mg/kg; p.o. or i.p.; single-dose) reaches the mouse brain tissue 15 min after administration^[1].
(R)-Phenylpiracetam (10, 25, 50 mg/kg; p.o.; pretreatment for 7 days) dose-dependently reduces paw oedema and the antinociceptive response on carrageenan induced mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

218.25

C₁₂H₁₄N₂O₂

949925-07-9

O=C(N)CN1C(C[C@H](C2=CC=CC=C2)C1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zvejniece L, et al. Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. Inflammopharmacology. 2020;28(5):1283-1292.  [Content Brief]

  [2]. Sommer S, et al. The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats. Int J Neuropsychopharmacol. 2014;17(12):2045-2056.  [Content Brief]