2. Neuronal Signaling
  3. Tau Protein
  4. (R)-TTBK1-IN-1

(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies. (R)-TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

(R)-TTBK1-IN-1 Chemical Structure

(R)-TTBK1-IN-1 Chemical Structure

CAS No. : 2735015-59-3

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5 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

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(R)-TTBK1-IN-1 Related Antibodies

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Description

(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1]. (R)-TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

337.38

Formula

C18H19N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@](C)(CC)C#CC1=CC2=C(C=CN2C3=CC(OC)=NC(N)=N3)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 33.33 mg/mL (98.79 mM; ultrasonic and adjust pH to 3 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9640 mL 14.8201 mL 29.6402 mL
5 mM 0.5928 mL 2.9640 mL 5.9280 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.9640 mL 14.8201 mL 29.6402 mL 74.1004 mL
5 mM 0.5928 mL 2.9640 mL 5.9280 mL 14.8201 mL
10 mM 0.2964 mL 1.4820 mL 2.9640 mL 7.4100 mL
15 mM 0.1976 mL 0.9880 mL 1.9760 mL 4.9400 mL
20 mM 0.1482 mL 0.7410 mL 1.4820 mL 3.7050 mL
25 mM 0.1186 mL 0.5928 mL 1.1856 mL 2.9640 mL
30 mM 0.0988 mL 0.4940 mL 0.9880 mL 2.4700 mL
40 mM 0.0741 mL 0.3705 mL 0.7410 mL 1.8525 mL
50 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.4820 mL
60 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2350 mL
80 mM 0.0371 mL 0.1853 mL 0.3705 mL 0.9263 mL
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(R)-TTBK1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-TTBK1-IN-12735015-59-3Tau Proteinbrain-penetrantalzheimer’s diseasetauopathiesTTBK1Inhibitorinhibitorinhibit

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