(R)-Vorbipiprant (Synonyms: (R)-CR6086)

Cat. No.: HY-163651: FAQs
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(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with K_i of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC₅₀ of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice.

For research use only. We do not sell to patients.

(R)-Vorbipiprant Chemical Structure

CAS No. : 2502965-92-4

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Other Forms of (R)-Vorbipiprant:

Vorbipiprant Get quote

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Description

IC₅₀ & Target

hEP4

16.6 nM (Ki)

Molecular Weight

472.50

Formula

C₂₆H₂₇F₃N₂O₃

CAS No.

2502965-92-4

SMILES

O=C(C1=CC=C(C2(CC2)NC([C@@H]3N(CCC4(C3)CC4)CC5=CC=C(C(F)(F)F)C=C5)=O)C=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Caselli G, et al., Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug. Arthritis Res Ther. 2018 Mar 1;20(1):39. [Content Brief]

(R)-Vorbipiprant Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Vorbipiprant2502965-92-4(R)-CR6086Prostaglandin ReceptorHEK293CIAarthritisLewis ratDBA/1 mouseorally activeInhibitorinhibitorinhibit

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