2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. (R)-Vorbipiprant

(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with Ki of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC50 of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice.

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(R)-Vorbipiprant Chemical Structure

(R)-Vorbipiprant Chemical Structure

CAS No. : 2502965-92-4

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(R)-Vorbipiprant Related Antibodies

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Description

(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with Ki of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC50 of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice[1].

IC50 & Target

hEP4

16.6 nM (Ki)

Molecular Weight

472.50

Formula

C26H27F3N2O3
CAS No.
SMILES

O=C(C1=CC=C(C2(CC2)NC([C@@H]3N(CCC4(C3)CC4)CC5=CC=C(C(F)(F)F)C=C5)=O)C=C1)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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(R)-Vorbipiprant Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Vorbipiprant2502965-92-4(R)-CR6086Prostaglandin ReceptorHEK293CIAarthritisLewis ratDBA/1 mouseorally activeInhibitorinhibitorinhibit

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