2. (R)-Zunsemetinib

(R)-Zunsemetinib  (Synonyms: (R)-ATI-450; (R)-CDD-450)

Cat. No.: HY-139553A Purity: 97.84% ee.: 100.00%
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(R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases.

For research use only. We do not sell to patients.

(R)-Zunsemetinib Chemical Structure

(R)-Zunsemetinib Chemical Structure

CAS No. : 1640282-44-5

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 540 In-stock
10 mg USD 940 In-stock
25 mg USD 1620 In-stock
50 mg USD 2600 In-stock
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Based on 1 publication(s) in Google Scholar

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(R)-Zunsemetinib Related Antibodies

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Description

(R)-Zunsemetinib is the isomer of Zunsemetinib (HY-139553), and can be used as an experimental control. Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1].

Molecular Weight

513.92

Formula

C25H22ClF2N5O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC(F)=CN=C1COC2=C(Cl)C(N(C3=CC(C4=NC(C(C)(C)O)=NC=C4)=NC=C3C)C(C)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (97.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9458 mL 9.7291 mL 19.4583 mL
5 mM 0.3892 mL 1.9458 mL 3.8917 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9458 mL 9.7291 mL 19.4583 mL 48.6457 mL
5 mM 0.3892 mL 1.9458 mL 3.8917 mL 9.7291 mL
10 mM 0.1946 mL 0.9729 mL 1.9458 mL 4.8646 mL
15 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
20 mM 0.0973 mL 0.4865 mL 0.9729 mL 2.4323 mL
25 mM 0.0778 mL 0.3892 mL 0.7783 mL 1.9458 mL
30 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
40 mM 0.0486 mL 0.2432 mL 0.4865 mL 1.2161 mL
50 mM 0.0389 mL 0.1946 mL 0.3892 mL 0.9729 mL
60 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.8108 mL
80 mM 0.0243 mL 0.1216 mL 0.2432 mL 0.6081 mL
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(R)-Zunsemetinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Zunsemetinib1640282-44-5(R)-ATI-450 (R)-CDD-450p38αmitogenactivatedkinaseimmuno-inflammatoryBMMsCAPSInhibitorinhibitorinhibit

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