2. Membrane Transporter/Ion Channel Apoptosis
  3. Proton Pump Apoptosis
  4. Rabeprazole-d4

Rabeprazole-d4  (Synonyms: LY307640-d4)

Cat. No.: HY-B0656S Purity: ≥95.0%
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Rabeprazole-d4 is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

For research use only. We do not sell to patients.

Rabeprazole-d<sub>4</sub> Chemical Structure

Rabeprazole-d4 Chemical Structure

CAS No. : 934295-48-4

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Based on 1 publication(s) in Google Scholar

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Rabeprazole-d4 Related Antibodies

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Description

Rabeprazole-d4 is a deuterium labeled Rabeprazole. Rabeprazole is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].

IC50 & Target

Pump inhibitor (PPI); UNH[1]
H+/K+-ATPase; Apoptosis[2]
Molecular Weight

363.47

Formula

C18H17D4N3O3S
CAS No.
Unlabeled CAS

117976-89-3
Appearance

Solid

Color

White to light brown

SMILES

COCCCOC(C=CN=C1CS(C2=NC3=C([2H])C([2H])=C([2H])C([2H])=C3N2)=O)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (57.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7513 mL 13.7563 mL 27.5126 mL
5 mM 0.5503 mL 2.7513 mL 5.5025 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7513 mL 13.7563 mL 27.5126 mL 68.7815 mL
5 mM 0.5503 mL 2.7513 mL 5.5025 mL 13.7563 mL
10 mM 0.2751 mL 1.3756 mL 2.7513 mL 6.8781 mL
15 mM 0.1834 mL 0.9171 mL 1.8342 mL 4.5854 mL
20 mM 0.1376 mL 0.6878 mL 1.3756 mL 3.4391 mL
25 mM 0.1101 mL 0.5503 mL 1.1005 mL 2.7513 mL
30 mM 0.0917 mL 0.4585 mL 0.9171 mL 2.2927 mL
40 mM 0.0688 mL 0.3439 mL 0.6878 mL 1.7195 mL
50 mM 0.0550 mL 0.2751 mL 0.5503 mL 1.3756 mL
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Rabeprazole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rabeprazole-d4934295-48-4LY307640-d4Proton PumpApoptosisprotonpumpPPIgastricATPaseuridinenucleosideribohydrolaseUNHulcerationsgastroesophagealrefluxInhibitorinhibitorinhibit

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