rac 8-Hydroxy Efavirenz-d₄ 

rac 8-Hydroxy Efavirenz-d₄ is the deuterium labeled rac 8-Hydroxy Efavirenz[1]. rac 8-Hydroxy Efavirenz-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

335.70

C₁₄H₅D₄ClF₃NO₃

1246812-30-5

205754-32-1

Solid

White to off-white

C(#CC1C(C1([2H])[2H])([2H])[2H])C2(C(F)(F)F)C=3C(NC(=O)O2)=C(O)C=C(Cl)C3

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]