2. NF-κB PI3K/Akt/mTOR
  3. NF-κB Akt
  4. (rac)-AG-205

(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway.

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(rac)-AG-205 Chemical Structure

(rac)-AG-205 Chemical Structure

CAS No. : 442656-02-2

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Based on 1 publication(s) in Google Scholar

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Description

(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].

Molecular Weight

454.98

Formula

C22H23ClN6OS
CAS No.
SMILES

CC1=CC2=C(C=C1)N(C3C2CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O
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Room temperature in continental US; may vary elsewhere.
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(rac)-AG-205 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rac)-AG-205442656-02-2NF-κBAktNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BPgrmc1INSIG1NF-kBneuronal resistanceInhibitorinhibitorinhibit

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