(Rac)-Bedaquiline-d₆ 

(Rac)-Bedaquiline-d₆ is the deuterium labeled Bedaquiline (HY-14881)^[1]. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit^[2]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

561.54

C₃₂H₂₅D₆BrN₂O₂

2517573-53-2

843663-66-1

Solid

White to off-white

BrC1=CC=C(N=C(OC)C(C(C(C2=CC=CC3=C2C=CC=C3)(O)CCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C4=CC=CC=C4)=C5)C5=C1

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]