(Rac)-Deox B 7,4 (Synonyms: (Rac)-Deoxysappanone B 7,4' dimethyl ether)

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(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity.

For research use only. We do not sell to patients.

(Rac)-Deox B 7,4 Chemical Structure

CAS No. : 674786-37-9

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	30.6 μM Compound: 3o	Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 29074256]
HeLa	IC₅₀	50.12 μM Compound: 3o	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 29074256]
Vero	IC₅₀	> 200 μM Compound: 3o	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 29074256]

In Vitro

(Rac)-Deox B 7,4 reduces the growth and viability of all tested AML cell lines with a submicromolar IC₅₀ (range 324-556 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

314.33

Formula

C₁₈H₁₈O₅

CAS No.

674786-37-9

SMILES

O=C1C(COC2=C1C=CC(OC)=C2)CC3=CC=C(C(O)=C3)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dannie Bernard, et al. Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. Apoptosis. 2015 Jul;20(7):948-59. [Content Brief]

(Rac)-Deox B 7,4 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Deox B 7,4674786-37-9(Rac)-Deoxysappanone B 7,4' dimethyl etherMicrotubule/TubulinTEXHL-60OCI-AML-2K562THP-1,Inhibitorinhibitorinhibit

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