1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. (Rac)-Deox B 7,4

(Rac)-Deox B 7,4  (Synonyms: (Rac)-Deoxysappanone B 7,4' dimethyl ether)

Cat. No.: HY-119361
Handling Instructions

(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity.

For research use only. We do not sell to patients.

(Rac)-Deox B 7,4 Chemical Structure

(Rac)-Deox B 7,4 Chemical Structure

CAS No. : 674786-37-9

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Description

(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity[1].

Cellular Effect
Cell Line Type Value Description References
BT-549 IC50
30.6 μM
Compound: 3o
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29074256]
HeLa IC50
50.12 μM
Compound: 3o
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29074256]
Vero IC50
> 200 μM
Compound: 3o
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29074256]
In Vitro

(Rac)-Deox B 7,4 reduces the growth and viability of all tested AML cell lines with a submicromolar IC50 (range 324-556 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

314.33

Formula

C18H18O5

CAS No.
SMILES

O=C1C(COC2=C1C=CC(OC)=C2)CC3=CC=C(C(O)=C3)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(Rac)-Deox B 7,4
Cat. No.:
HY-119361
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