(Rac)-ErSO-DFP

Cat. No.: HY-144070A: FAQs
Data Sheet Handling Instructions Technical Support

(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1).

For research use only. We do not sell to patients.

(Rac)-ErSO-DFP Chemical Structure

CAS No. : 2768139-73-5

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Other Forms of (Rac)-ErSO-DFP:

ErSO-DFP Get quote

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 35 nM (MCF-7 cells)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	0.035 μM Compound: 2	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 24 hrs by alamar blue assay	[PMID: 35080871]

In Vitro

(Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC₅₀ of 35 nM in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	0.001-1 µM
Incubation Time:	24 h
Result:	Showed a sustained activity of anticancer with IC₅₀ of 35 nM.

In Vivo

(Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)^[1].
Dosage:	5 mg/kg
Administration:	Intravenous injection; once-a-week for 3 total doses.
Result:	Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.

Molecular Weight

412.35

Formula

C₂₀H₁₇F₅N₂O₂

CAS No.

2768139-73-5

SMILES

O=C1NC2=C(C=CC=C2C1(N3CCC(F)(CC3)F)C4=CC=C(C=C4)O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hergenrother, et al. Enzyme-activating compounds and compositions. Patent WO2022087234A1.

(Rac)-ErSO-DFP Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-ErSO-DFP2768139-73-5Estrogen Receptor/ERRERαresistant tumorsbreast cancerErSO-DFPa-UPRInhibitorinhibitorinhibit

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