2. Apoptosis
  3. Apoptosis
  4. (Rac)-Idroxioleic acid sodium

(Rac)-Idroxioleic acid sodium  (Synonyms: 2-Hydroxyoleic acid sodium; 2-OHOA sodium; LAM561 sodium)

Cat. No.: HY-129467A
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(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid sodium has anti-tumor effect.

For research use only. We do not sell to patients.

(Rac)-Idroxioleic acid sodium Chemical Structure

(Rac)-Idroxioleic acid sodium Chemical Structure

CAS No. : 1229114-68-4

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(Rac)-Idroxioleic acid sodium Related Antibodies

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Description

(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid sodium has anti-tumor effect[1].

In Vitro

(Rac)-Idroxioleic acid sodium (25-75 μM; 72 h) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].
(Rac)-Idroxioleic acid sodium (25-50 μM; 72 h) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Idroxioleic acid sodium Related Antibodies

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM, 75 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Impaired Jurkat cell growth in a time- and concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 25 μM, 50 μM
Incubation Time: 72 hours
Result: Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.
In Vivo

(Rac)-Idroxioleic acid sodium markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
Dosage: 600 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Markedly and significantly inhibited tumour growth.
Molecular Weight

320.44

Formula

C18H33NaO3
CAS No.
SMILES

O=C(O[Na])C(O)CCCCCC/C=C\CCCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(Rac)-Idroxioleic acid sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Idroxioleic acid1229114-68-42-Hydroxyoleic acid2-OHOALAM561LAM 561LAM-561ApoptosisoleicacidplasmamembraneInhibitorinhibitorinhibit

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