(rac)-ONO-2050297

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(rac)-ONO-2050297 is a benzoxazole derivative and a potent biCysLT1/CysLT2 antagonist with IC₅₀ values ??are 17 nM and 0.87 nM respectively.

For research use only. We do not sell to patients.

(rac)-ONO-2050297 Chemical Structure

CAS No. : 1637756-67-2

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•Related Small Molecules:

•Related Proteins:

View All Leukotriene Receptor Isoform Specific Products:

View All Isoforms

LTB₄ LTC₄/CysLT₂ LTD₄/CysLT₁ LTE₄

Biological Activity
Purity & Documentation
References
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Description

(rac)-ONO-2050297 is a benzoxazole derivative and a potent biCysLT1/CysLT2 antagonist with IC₅₀ values ??are 17 nM and 0.87 nM respectively^[1].

IC₅₀ & Target

CysLT1/CysLT2^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.017 μM Compound: 19, ONO-2050297	Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	[PMID: 25408836]
HEK293	IC₅₀	0.00087 μM Compound: 19, ONO-2050297	Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay	[PMID: 25408836]

Molecular Weight

546.61

Formula

C₃₁H₃₄N₂O₇

CAS No.

1637756-67-2

SMILES

O=C(O)CCCCN1CC(C(O)=O)OC2=C(NC(C3=CC=C(OCCCCC4=CC=CC=C4)C=C3)=O)C=CC=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist

(rac)-ONO-2050297 Related Classifications

Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rac)-ONO-20502971637756-67-2Leukotriene ReceptorInhibitorinhibitorinhibit

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