(±)5,6-DHET lactone (Synonyms: (±)5,6-DiHETrE lactone)

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5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.

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(±)5,6-DHET lactone Chemical Structure

CAS No. : 213126-92-2

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Description	5,6-DiHET lactone ((±)5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5(6)-EET degrades into 5(6)-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.
Molecular Weight	320.47
Formula	C₂₀H₃₂O₃
CAS No.	213126-92-2
SMILES	O=C1CCCC(C(O)C/C=C\C/C=C\C/C=C\CCCCC)O1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (260 KB) Handling Instructions (2659 KB)
References	[1]. Oltman, et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83(9), 932-939 (1998).

(±)5,6-DHET lactone Related Classifications

Cardiovascular Disease

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(±)5,6-DHET lactone213126-92-2(±)5,6-DiHETrE lactoneOthersInhibitorinhibitorinhibit

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(±)5,6-DHET lactone (Synonyms: (±)5,6-DiHETrE lactone)

(±)5,6-DHET lactone Related Antibodies

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