(±)-Duloxetine-d₃ hydrochloride  (Synonyms: (Rac)-Duloxetine-d₃ hydrochloride)

(±)-Duloxetine-d₃ (hydrochloride) is deuterium labeled (±)-Duloxetine (hydrochloride). (±)-Duloxetine ((Rac)-Duloxetine) hydrochloride is the racemate of Duloxetine hydrochloride. Duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor, can be used for diabetic neuropathic pain and fibromyalgia as well as major depressive disorder research[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

336.89

C₁₈H₁₇D₃ClNOS

947316-47-4

[2H]C(NCCC(OC1=C2C=CC=CC2=CC=C1)C3=CC=CS3)([2H])[2H].[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Mermi O, et al. [Duloxetine-Induced Hypertension: A Case Report]. Turk Psikiyatri Derg. 2016;27(1):67-69.  [Content Brief]