(±)-JQ1

Cat. No.: HY-137075: FAQs
Data Sheet Handling Instructions

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(±)-JQ1 is the racemate of (+)-JQ-1 (HY-13030).

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(±)-JQ1 Chemical Structure

CAS No. : 1268524-69-1

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Biological Activity
Purity & Documentation
References
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Description

(±)-JQ1 is the racemate of (+)-JQ-1 (HY-13030)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	EC₅₀	2037 nM Compound: 2; JQ-1	Antiproliferative activity against human CCRF-CEM cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human CCRF-CEM cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
DOHH-2	EC₅₀	279 nM Compound: 2; JQ-1	Antiproliferative activity against human DOHH2 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human DOHH2 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
HEK293	CC₅₀	> 20 μM Compound: JQ1	Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay	[PMID: 30973727]
HEL 92.1.7	EC₅₀	180 nM Compound: 2; JQ-1	Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human HEL 92.1.7 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
HepG2	CC₅₀	9.2 μM Compound: JQ1	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay	[PMID: 30973727]
HL-60	EC₅₀	51 nM Compound: 2; JQ-1	Antiproliferative activity against human HL60 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human HL60 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
K562	EC₅₀	> 10000 nM Compound: 2; JQ-1	Antiproliferative activity against human K562 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human K562 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
MCF7	IC₅₀	28.75 μM Compound: 1; JQ1	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 29172540]
MDA-MB-231	IC₅₀	33.04 μM Compound: 1; JQ1	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 29172540]
MV4-11	EC₅₀	39 nM Compound: 2; JQ-1	Antiproliferative activity against human MV4-11 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human MV4-11 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
Raji	EC₅₀	330 nM Compound: 2; JQ-1	Antiproliferative activity against human Raji cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human Raji cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
RPMI-8226	EC₅₀	258 nM Compound: 2; JQ-1	Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human RPMI8226 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]
SUD4	EC₅₀	660 nM Compound: 2; JQ-1	Antiproliferative activity against human SU-DHL4 cells after 72 hrs by Cell-TiterGlo assay Antiproliferative activity against human SU-DHL4 cells after 72 hrs by Cell-TiterGlo assay	[PMID: 29259751]

Molecular Weight

456.99

Formula

C₂₃H₂₅ClN₄O₂S

CAS No.

1268524-69-1

SMILES

O=C(OC(C)(C)C)CC1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shameem Sultana Syeda, et al. Scalable syntheses of the BET bromodomain inhibitor JQ1. Tetrahedron Lett. 2015 Jun 3;56(23):3354-3457. [Content Brief]

(±)-JQ1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-JQ11268524-69-1Epigenetic Reader DomainBET inhibitorsTriazolothienodiazepine (+)-JQ1racemateInhibitorinhibitorinhibit

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