Radalbuvir (Synonyms: GS-9669)

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Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC₅₀ = 2.9 nM, GT1b EC₅₀ = 6 nM).

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Radalbuvir Chemical Structure

CAS No. : 1314795-11-3

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	11 nM Compound: 53, GS-9669	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	128 nM Compound: 53, GS-9669	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as plasma adjusted antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as plasma adjusted antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	14 nM Compound: 53, GS-9669	Antiviral activity against HCV genotype 1b harboring NS5B polymerase M423T mutant infected in human HuH7-Lunet cells by luciferase reporter gene assay Antiviral activity against HCV genotype 1b harboring NS5B polymerase M423T mutant infected in human HuH7-Lunet cells by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	2.9 nM Compound: 53, GS-9669	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	6 nM Compound: 53, GS-9669	Antiviral activity against HCV genotype 1b harboring wild type NS5B polymerase infected in human HuH7-Lunet cells by luciferase reporter gene assay Antiviral activity against HCV genotype 1b harboring wild type NS5B polymerase infected in human HuH7-Lunet cells by luciferase reporter gene assay	[PMID: 24144213]
MT4	CC₅₀	> 20 μM Compound: 53, GS-9669	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]
MT4	CC₅₀	12138 nM Compound: 53, GS-9669	Intrinsic cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Intrinsic cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

In Vitro

Radalbuvir (GS-9669) shows high in vitro metabolic stability, long residence time in rats, and maintained high activity against the NS5B M423T mutation (GT1b M423T EC₅₀ = 14 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

543.71

Formula

C₃₀H₄₁NO₆S

CAS No.

1314795-11-3

SMILES

O=C([C@@H]1CCC(C)=CC1)N([C@H]2CC[C@@](CO[C@H]3CCOC3)(O)CC2)C(C=C(C#CC(C)(C)C)S4)=C4C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou Z, et al. Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective. Eur J Med Chem. 2022 Jul 8;240:114595. [Content Brief]

Radalbuvir Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Radalbuvir1314795-11-3GS-9669GS9669GS 9669HCVHepatitis C virusnon-nucleoside inhibitorNS5BRdRpnonstructural protein 5BRNA-dependent RNA polymeraseanti-HCVhigh in vitro metabolic stabilityInhibitorinhibitorinhibit

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Radalbuvir (Synonyms: GS-9669)

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