Ralfinamide mesylate (Synonyms: FCE-26742A mesylate)

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Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na⁺ channel blocker derived from α-aminoamide, with function of suppressing pain.

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Ralfinamide mesylate Chemical Structure

CAS No. : 202825-45-4

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Other Forms of Ralfinamide mesylate:

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1 Publications Citing Use of MCE Ralfinamide mesylate

•Acta Pharmacol Sin. 2021 Aug;42(8):1235-1247. [Abstract]

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Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
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Description

Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na⁺ channel blocker derived from α-aminoamide, with function of suppressing pain^[1]^[2].

IC₅₀ & Target

Na⁺channel^[1]

In Vivo

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	81 adult male Sprague–Dawley male rats (260–460 g)^[1]
Dosage:	80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
Administration:	Oral gavage; twice daily; until postoperative day 42
Result:	Suppressed neuropathic pain.

Clinical Trial

Molecular Weight

398.45

Formula

C₁₈H₂₃FN₂O₅S

CAS No.

202825-45-4

SMILES

C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang SH, et al. Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain. 2008 Oct 15;139(2):293-305. [Content Brief]

[2]. Liang X, et al. Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. Eur J Pharmacol. 2018 Mar 15;823:27-34. [Content Brief]

Ralfinamide mesylate Related Classifications

Neurological Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ralfinamide202825-45-4FCE-26742ASodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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