2. Immunology/Inflammation
  3. NO Synthase
  4. Randaiol

Randaiol is an antioxidant that can be isolated from the stem bark of Magnolia officinalis. Randaiol inhibits LPS-induced NO production and has anti-inflammatory and antioxidant activities.

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Randaiol Chemical Structure

Randaiol Chemical Structure

CAS No. : 87562-14-9

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Randaiol Related Antibodies

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nNOS iNOS eNOS

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Description

Randaiol is an antioxidant that can be isolated from the stem bark of Magnolia officinalis. Randaiol inhibits LPS-induced NO production and has anti-inflammatory and antioxidant activities[1].

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
1.2 μg/mL
Compound: 6
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess reagent method
[PMID: 19086868]
HCC827 IC50
> 40 μM
Compound: 13
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay
[PMID: 30006164]
HepG2 2.2.15 IC50
> 1000 μM
Compound: 8
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBV DNA replication after 72 hrs by PCR analysis
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBV DNA replication after 72 hrs by PCR analysis
[PMID: 23434030]
HepG2 2.2.15 IC50
162.43 μM
Compound: 8
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBsAg secretion after 12 days by ELISA
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBsAg secretion after 12 days by ELISA
[PMID: 23434030]
HepG2 2.2.15 CC50
200.57 μM
Compound: 8
Cytotoxicity against human HepG2(2.2.15) cells after 12 days by MTT assay
Cytotoxicity against human HepG2(2.2.15) cells after 12 days by MTT assay
[PMID: 23434030]
HepG2 2.2.15 IC50
30.24 μM
Compound: 8
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBeAg secretion after 12 days by ELISA
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBeAg secretion after 12 days by ELISA
[PMID: 23434030]
NCI-H1975 IC50
> 40 μM
Compound: 13
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay
[PMID: 30006164]
NCI-H460 IC50
> 40 μM
Compound: 13
Antiproliferative activity against human H460 cells after 72 hrs by MTT assay
Antiproliferative activity against human H460 cells after 72 hrs by MTT assay
[PMID: 30006164]
Molecular Weight

242.27

Formula

C15H14O3
CAS No.
SMILES

OC1=CC=C(O)C=C1C2=CC(CC=C)=CC=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Randaiol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Randaiol87562-14-9Magnotriol ANO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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