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  3. Isotope-Labeled Compounds
  4. Rapamycin-13C,d3

Rapamycin-13C,d3  (Synonyms: Sirolimus-13C,d3; AY-22989-13C,d3)

Cat. No.: HY-10219S1 Purity: 97.05%
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Rapamycin-13C,d3 (Sirolimus-13C,d3; AY-22989-13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.

For research use only. We do not sell to patients.

Rapamycin-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Rapamycin-13C,d3 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Rapamycin-13C,d3:

Rapamycin-13C,d3 Related Antibodies

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Description

Rapamycin-13C,d3 (Sirolimus-13C,d3; AY-22989-13C,d3) is the 13C and deuterium labeled Rapamycin (HY-10219)[1]. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[2]. Rapamycin is an autophagy activator, an immunosuppressant[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rapamycin-13C,d3 Related Antibodies
Molecular Weight

918.18

Formula

C5013CH76D3NO13
Unlabeled CAS

53123-88-9
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)O[13C]([2H])([2H])[2H])O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (136.14 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0891 mL 5.4456 mL 10.8911 mL
5 mM 0.2178 mL 1.0891 mL 2.1782 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0891 mL 5.4456 mL 10.8911 mL 27.2278 mL
5 mM 0.2178 mL 1.0891 mL 2.1782 mL 5.4456 mL
10 mM 0.1089 mL 0.5446 mL 1.0891 mL 2.7228 mL
15 mM 0.0726 mL 0.3630 mL 0.7261 mL 1.8152 mL
20 mM 0.0545 mL 0.2723 mL 0.5446 mL 1.3614 mL
25 mM 0.0436 mL 0.2178 mL 0.4356 mL 1.0891 mL
30 mM 0.0363 mL 0.1815 mL 0.3630 mL 0.9076 mL
40 mM 0.0272 mL 0.1361 mL 0.2723 mL 0.6807 mL
50 mM 0.0218 mL 0.1089 mL 0.2178 mL 0.5446 mL
60 mM 0.0182 mL 0.0908 mL 0.1815 mL 0.4538 mL
80 mM 0.0136 mL 0.0681 mL 0.1361 mL 0.3403 mL
100 mM 0.0109 mL 0.0545 mL 0.1089 mL 0.2723 mL
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Rapamycin-13C,d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rapamycin-13C,d3Sirolimus-13C,d3 AY-22989-13C,d3Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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