2. MAPK/ERK Pathway Stem Cell/Wnt TGF-beta/Smad Epigenetics
  3. p38 MAPK ERK PKC
  4. Raxofelast

Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression.

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Raxofelast Chemical Structure

Raxofelast Chemical Structure

CAS No. : 128232-14-4

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Raxofelast Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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ERK ERK1 ERK2 ERK5 ERK8

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H2O2-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression[1].

Molecular Weight

278.30

Formula

C15H18O5
CAS No.
SMILES

O=C(CC1OC2=C(C1)C(C)=C(OC(C)=O)C(C)=C2C)O
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Raxofelast Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Raxofelast128232-14-4IRFI-016IRFI016IRFI 016p38 MAPKERKPKCExtracellular signal regulated kinasesProtein kinase CAntioxidant;oxidation-reductionAntiproliferativeInhibitorinhibitorinhibit

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