ABAT Protein, Human (His, SUMO, Myc)

ABAT Protein, Human (His, SUMO, Myc) is a γ-Aminobutyric acid transaminase which is responsible for GABA metabolism. ABAT, Human is implicated in mitochondrial nucleoside metabolism, respiratory capacity, membrane potential, and mitochondrial DNA maintenance.

GABA transaminase (ABAT) is the protein responsible for GABA metabolism. ABAT mediates the GABA metabolic pathway, a bypass mechanism in the tricarboxylic acid cycle (TCAC), producing succinate and NADH. γ-Aminobutyric acid (GABA), routinely described as an inhibitory neurotransmitter, is found in high concentrations in the neural parenchyma and has various roles in the CNS. Elevated ABAT expression results in increased GABA catabolism, decreased tumor cell proliferation. In mammals, reduced ABAT expression is implicated in primary clear cell renal carcinoma, breast cancer, and myelodysplastic syndrome tumorigenesis. ABAT has been shown to be implicated in mitochondrial nucleoside metabolism, respiratory capacity, membrane potential, and mitochondrial DNA maintenance^[1].

Human

E. coli

C-Myc;N-10*His;N-SUMO

P80404 (S29-K500)

18  [NCBI]

SQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK

Approximately 69 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Martirosian V, et, al. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jun 29;35(13):109302.  [Content Brief]