ACSS2 Protein, Human (His)

The ACSS2 protein plays a key role in catalyzing the synthesis of acetyl-CoA from short-chain fatty acids, with acetate being the preferred substrate. Although acetate is efficiently utilized, ACSS2 can also process propionate, albeit with significantly lower affinity. ACSS2 Protein, Human (His) is the recombinant human-derived ACSS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ACSS2 Protein, Human (His) is 700 a.a., .

ACSS2 (Acetyl-CoA synthetase 2) is an enzyme that plays a crucial role in cellular metabolism by catalyzing the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate for ACSS2, and it efficiently converts acetate into acetyl-CoA. This enzymatic activity is pivotal for various cellular processes, including energy production, lipid metabolism, and histone acetylation. ACSS2 can also utilize propionate, albeit with a much lower affinity compared to acetate. The ability of ACSS2 to generate acetyl-CoA from short-chain fatty acids contributes to the pool of acetyl-CoA available for diverse metabolic pathways, emphasizing its importance in cellular energy homeostasis and the integration of metabolic signals.

Human

E. coli

N-6*His

Q9NR19-1 (G2-Q701)

55902

80.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of 50 mM HEPES (pH 7.0), 200 mM NaCl, 20% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.