ACY3 Protein, Human (His)

ACY3 Protein, Human (His) is human recombinant ACY3 with a N-terminal His tag. ACY3 Protein, Human (His) plays an important role in deacetylating mercapturic acids in kidney proximal tubules^[1][2].

ACY3 (Aspartoacylase 3) is an aspartoacylase, and locates at 11q13.2. The length of its sequence is 959 bases, encoding 319aa. ACY3 plays an important role in deacetylating mercapturic acids in kidney proximal tubules. ACY3 mediates deacetylation of N-acetyl-Lamino acids to give fatty acids and amino acids as products. ACY3 also deacetylated N-acetyl-L-histidine and N-acetyl-L-methionine. ACY3 is capable of binding to HCV core protein^[1][2].

Human

E. coli

N-6*His

Q96HD9 (M1-S319)

91703  [NCBI]

HHHHHHMCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS

Approximately 35.0 kDa

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Chen YR, et al. Identification of a novel protein binding to hepatitis C virus core protein. J Gastroenterol Hepatol. 2009 Jul;24(7):1300-4.  [Content Brief]

  [2]. Newman D, et al.Specificity of aminoacylase III-mediated deacetylation of mercapturic acids. Drug Metab Dispos. 2007 Jan;35(1):43-50.  [Content Brief]