Adiponectin/Acrp30 Protein, Cynomolgus (HEK293, His)

Adiponectin/Acrp30 protein regulates fat metabolism and insulin sensitivity and has antidiabetic, antiatherosclerotic, and anti-inflammatory effects. It stimulates AMPK phosphorylation, enhancing glucose utilization and fatty acid burning. Adiponectin/Acrp30 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Adiponectin/Acrp30 protein, expressed by HEK293 , with C-His labeled tag. The total length of Adiponectin/Acrp30 Protein, Cynomolgus (HEK293, His) is 227 a.a., with molecular weight of 30-40 kDa.

Adiponectin/Acrp30 protein stands as a crucial adipokine with significant implications in the regulation of fat metabolism and insulin sensitivity, exerting direct anti-diabetic, anti-atherogenic, and anti-inflammatory effects. Its influence extends to the stimulation of AMPK phosphorylation and activation in the liver and skeletal muscle, thereby enhancing glucose utilization and fatty-acid combustion. Adiponectin/Acrp30 plays a pivotal role in dampening the pro-inflammatory effects of TNF-alpha by negatively regulating its expression in various tissues, including the liver and macrophages, and counteracting its downstream effects. Furthermore, it exhibits the ability to inhibit endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Beyond its metabolic functions, Adiponectin/Acrp30 may contribute to cell growth, angiogenesis, and tissue remodeling by binding and sequestering various growth factors, with distinct affinities depending on the type of complex formed—LMW, MMW, or HMW. Notably, the polymerization and secretion of adiponectin are subject to inhibition by succination of cysteine residues, a process mediated by the Krebs cycle intermediate fumarate, leading to the formation of S-(2-succinyl)cysteine residues. These intricate mechanisms highlight the multifaceted role of Adiponectin/Acrp30 in orchestrating metabolic, anti-inflammatory, and growth-related processes.

Cynomolgus

HEK293

C-His

A0A2K5X7X6 (Q48-N274)

102123471  [NCBI]

30-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.