1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Macrophage CD Proteins Stem Cell CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. ALCAM/CD166 Immunoglobulin-like Cell Adhesion Molecules
  5. Activated Leukocyte Cell Adhesion Molecule (ALCAM)
  6. ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc)

ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc)

Cat. No.: HY-P76776
Handling Instructions

ALCAM/CD166 Protein is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM/CD166 has emerged as a modulator of cancer progression, mainly by controlling cell proliferation, adhesion, migration and invasion. ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived ALCAM/CD166 protein, expressed by HEK293 , with C-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

ALCAM/CD166 Protein is a glycoprotein involved in homotypic and heterotypic cell adhesion. ALCAM/CD166 has emerged as a modulator of cancer progression, mainly by controlling cell proliferation, adhesion, migration and invasion[1]. ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived ALCAM/CD166 protein, expressed by HEK293 , with C-hFc labeled tag.

Background

Activated Leukocyte Cell Adhesion Molecule (ALCAM) or cluster of differentiation 166 (CD166) is a cell surface glycoprotein structurally related to the immunoglobulin superfamily molecules, initially identified on activated leukocytes. ALCAM is also found in epithelial cells, vascular endothelial cells, neurons, myeloid progenitors, hematopoietic stem cells, mesenchymal stem cells, bone marrow stromal cells, tumor cells and cancer stem cells. ALCAM can be proteolytically cleaved at the cell surface by metalloproteases, which generate shedding of its ectodomain. In normal physiology, ALCAM has been shown to modulate cell-cell interactions with lymphocytes as well as epithelial and endothelial cells. Besides cell adhesion, other ALCAM functions have been described such as angiogenesis, transmigration of monocytes, leukocyte intravasation across blood brain barrier, T cell activation, hematopoiesis, neurite extension, osteogenesis, and embryonic implantation in the uterus[1].

Species

Cynomolgus

Source

HEK293

Tag

C-hFc

Accession

G7NZQ8 (G27-A526)

Gene ID

/

Molecular Construction
N-term
ALCAM (G27-A526)
Accession # G7NZQ8
hFc
C-term
Synonyms
ALCAM; CD166 antigen; Activated leukocyte cell adhesion molecule; MEMD
Molecular Weight

Approximately 82.9 kDa.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
ALCAM/CD166 Protein, Cynomolgus (HEK293, Fc)
Cat. No.:
HY-P76776
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