Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, C-His)

The alkaline phosphatase/ALPL protein is critical for phosphatase, metal ion binding, and homodimerization activities, affecting BMP stimulation responses. It is strategically located outside the plasma membrane and its predicted activity emphasizes cellular function. Alkaline Phosphatase/ALPL Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived Alkaline Phosphatase/ALPL protein, expressed by HEK293 , with C-His labeled tag.

Alkaline Phosphatase/ALPL Protein is predicted to play several vital roles, including alkaline phosphatase activity, metal ion binding activity, and protein homodimerization activity. It functions upstream of or within the cellular response to BMP stimulus, suggesting its involvement in critical signaling pathways. The protein is predicted to be strategically located in the external side of the plasma membrane, indicating its role in extracellular processes. Its predicted activity in the plasma membrane further emphasizes its significance in cellular functions. This protein is expressed prominently in the intestine and testis, and the biased expression profile in duodenum adult (RPKM 2234.3), small intestine adult (RPKM 1574.5), and one other tissue underscores its specific roles in these physiological contexts. The human ortholog(s) of this gene have been implicated in inflammatory bowel disease, further highlighting its clinical relevance. Alkaline Phosphatase/ALPL is evolutionarily conserved, with orthologous counterparts such as ALPI (alkaline phosphatase, intestinal) in several human genes.

Mouse

HEK293

C-His

F8VPQ6/NP_001074551.1 (I21-G501)

76768  [NCBI]

60-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.