AMCase/CHIA Protein, Mouse (HEK293, His)

AMCase/CHIA Protein, an enzyme, is a member of the chitinase family that hydrolyzes chitin, a component of the fungal cell wall. It plays a crucial role in the immune response against fungal infections. AMCase/CHIA Protein's potential as a therapeutic target lies in its ability to modulate the immune system and its involvement in allergic diseases and asthma. AMCase/CHIA Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMCase/CHIA protein, expressed by HEK293 , with C-His labeled tag. The total length of AMCase/CHIA Protein, Mouse (HEK293, His) is 452 a.a., with molecular weight of 53-60 kDa.

AMCase/CHIA Protein is an important enzyme involved in the degradation of chitin and chitotriose, which are essential components of the cell walls of fungi, nematodes, and other pathogens. This protein is believed to play a significant role in the defense against these pathogens, contributing to the body's immune response, particularly the T-helper cell type 2 (Th2) immune response. It is also involved in the response to interleukin-13 (IL-13) and the subsequent inflammation caused by IL-13. Additionally, AMCase/CHIA Protein stimulates the production of chemokines by pulmonary epithelial cells and protects lung epithelial cells from apoptosis, promoting the phosphorylation of AKT1. Its ability to function in the inflammatory response and protect cells against apoptosis is hindered by allosamidin, indicating that carbohydrate binding is crucial for its function. The presence of AMCase/CHIA Protein in saliva and gastric juice further suggests its role as a digestive enzyme.

Mouse

HEK293

C-His

Q91XA9 (Y22-P473)

81600  [NCBI]

53-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.