Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc)

The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Angiopoietin-1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc) is 222 a.a., with molecular weight of ~54.1 KDa.

ANGPT1 encodes a secreted glycoprotein in the angiopoietin family and is a key ligand in the vasotyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. The Angiopoietin-1 Protein regulates the formation and stability of blood vessels and plays an important role in vascular development. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells^[1][2][3].

Determined by its ability to induce adhesion of human umbilical vein endothelial cells (HUVEC).The ED₅₀ for this effect is 252.3 ng/mL.

Cynomolgus

HEK293

N-hFc

XP_005563980 (R277-F498)

102123994  [NCBI]

Approximately 54.1 kDa.

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, 10%glycerol, 4%Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.