2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Angiopoietins
  5. ANG-1

ANG-1

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Angiopoietins are a family of vascular growth factors that are ligands for the tyrosine kinase receptor Tie-2. Angiopoietins acts primarily on the vasculature to control blood vessel development and stability. Four distinct angiopoietins have been described: Ang-1, Ang-2, Ang-3 and Ang-4. Structurally, the angiopoietins contain an N-terminal super clustering domain (SCD), a central coiled-coil domain (CCD) responsible for ligand homo-oligomerization, a linker region, and a C-terminal fibrinogen-related domain (FReD) required for binding to the Tie-2 receptor. Angiopoietins bind the second immunoglubulin motif of Tie-2 whereby they activate Tie-2 and, indirectly, Tie-1 in Tie-1/Tie-2 heterodimers. Angiopoietins (ANG1-ANG4) and the Tie-1/2 form an endothelial signalling pathway that is necessary for embryonic cardiovascular and lymphatic development. In adults, this system regulates vascular homeostasis, and controls vessel permeability, inflammation and angiogenic responses. Ang-1 and Ang-2 are the most exhaustively studied angiopoietins. Ang-1 is a critical player in vessel maturation and it mediates migration, adhesion and survival of endothelial cells. Ang-2 disrupts the connections between the endothelium and perivascular cells and promotes cell death and vascular regression.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70061
    Angiopoietin-1 Protein, Human (HEK293, Fc)

    rHuAngiopoietin-1/ANG1, Fc; AGP1; AGPT; Ang1; ANG-1; angiopoietin 1; Angiopoietin-1; ANGPT1

    		Human HEK293
    Angiopoietin-1 Protein, Human (HEK 293, Fc) is a secreted protein located on the outside of cell membranes and is an agonistic ligand of receptor tyrosine kinase that is mainly expressed by vascular endothelial cells and hematopoietic cells. Angiopoietin-1 Protein, Human (HEK 293, Fc) is a potent inducer of sprouting angiogenesis, proming for research of colorectal cancer liver metastases (CRCLMs). Angiopoietin-1 Protein, Human (HEK 293, Fc) induces vascular remodeling through highly organized angiogenesis and tightening of endothelial cell (EC) junctions. Angiopoietin-1 Protein, Human (HEK 293, Fc) regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and maintenance of vascular quiescence. Angiopoietin-1 Protein, Human (HEK 293, Fc) is a recombinant protein with a Fc label that consisting of 498 amino acids and is expressed in HEK293 cells.
  • HY-P74412
    Angiopoietin-1 Protein, Mouse (HEK293, His, solution)

    AGP1; AGPT; ANG-1; Angiopoietin-1; ANGPT1

    		Mouse HEK293
    Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.
  • HY-P76145
    Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc)

    AGP1; AGPT; ANG-1; Angiopoietin-1; ANGPT1

    		Cynomolgus HEK293
    The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Angiopoietin-1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Angiopoietin-1 Protein, Cynomolgus (HEK293, Fc) is 222 a.a., with molecular weight of ~54.1 KDa.
  • HY-P76146
    Angiopoietin-1 Protein, Cynomolgus (HEK293, His)

    AGP1; AGPT; ANG-1; Angiopoietin-1; ANGPT1

    		Cynomolgus HEK293
    The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. Angiopoietin-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.
  • HY-P74412A
    Angiopoietin-1 Protein, Mouse (HEK293, His)

    AGP1; AGPT; ANG-1; Angiopoietin-1; ANGPT1

    		Mouse HEK293
    Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag.
  • HY-P700560
    ANGPT1/Angiopoietin-1, Rat (P. pastoris, His)

    angiopoietin 1; angiopoietin-1; Ang1; KIAA0003; ANG-1; AGP1; AGPT; ANG1;

    		Rat P. pastoris
    In rats, ANGPT1 (Angiopoietin-1) activates the TIE2 receptor, inducing tyrosine phosphorylation and influencing endothelial developmental processes distinct from VEGF. ANGPT1 plays a crucial role in mediating reciprocal interactions between endothelium, matrix, and mesenchyme. It participates in blood vessel maturation, emphasizing its significance in vascular development, with a potential role in early heart development. ANGPT1/Angiopoietin-1, Rat (P. pastoris, His) is the recombinant rat-derived ANGPT1/Angiopoietin-1, Rat, expressed by P. pastoris, with N-6*His labeled tag. The total length of ANGPT1/Angiopoietin-1, Rat (P. pastoris, His) is 478 a.a., with molecular weight of 57.4 kDa.
Cat. No. Product Name Effect Purity